abstract：BACKGROUND & AIMS:Data on acute exacerbation and reactivation of chronic hepatitis C virus (HCV) infection following chemotherapy are very limited. We sought to characterize the episodes of acute exacerbation and viral reactivation of HCV infection in cancer patients. METHODS:The medical records of HCV-infected patien...

journal_title：Journal of hepatology

authors： Mahale P,Kontoyiannis DP,Chemaly RF,Jiang Y,Hwang JP,Davila M,Torres HA

更新日期：2012-12-01 00:00:00

abstract：:Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define ...

journal_title：Journal of hepatology

authors： Jalan R,Gines P,Olson JC,Mookerjee RP,Moreau R,Garcia-Tsao G,Arroyo V,Kamath PS

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND & AIMS:Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LD...

journal_title：Journal of hepatology

authors： Hu A,Liang W,Zheng Z,Guo Z,He X

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND & AIMS:Although antiviral treatment for hepatitis C (HCV) is highly effective, side effects often occur, including weight loss, digestive symptoms, and impaired quality of life. We aimed at exploring the beneficial effects of preventive nutritional support. METHODS:In a randomized controlled trial, 53 HCV p...

journal_title：Journal of hepatology

authors： Huisman EJ,van Hoek B,van Soest H,van Nieuwkerk KM,Arends JE,Siersema PD,van Erpecum KJ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:Fetal safety of antiviral therapies is important given the long-term treatment of women with chronic hepatitis B (CHB) infection who may become pregnant. We analyzed neonatal safety data from the Antiretroviral Pregnancy Registry (APR), the largest safety database in pregnancy for antivirals used for ...

journal_title：Journal of hepatology

authors： Brown RS Jr,Verna EC,Pereira MR,Tilson HH,Aguilar C,Leu CS,Buti M,Fagan EA

更新日期：2012-11-01 00:00:00

abstract：:HCV infection is a global health problem that affects 170 million people worldwide. The severity of the disease varies from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma (HCC). Recently, the standard of care for genotype 1 patients has greatly improved with the addition of protease inhibitor...

journal_title：Journal of hepatology

authors： Estrabaud E,Vidaud M,Marcellin P,Asselah T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary tree, liver, and pancreas share a common embryological origin. We previously demonstrated the presence of stem/progenitor cells of endodermal origin in the adult human extrahepatic biliary tree. This study evaluated the human foetal biliary trees as sources of stem/progenitor cells of multiple...

journal_title：Journal of hepatology

authors： Semeraro R,Carpino G,Cardinale V,Onori P,Gentile R,Cantafora A,Franchitto A,Napoli C,Anceschi M,Brunelli R,Bosco D,Torrice A,Reid L,Gaudio E,Alvaro D

更新日期：2012-11-01 00:00:00

abstract：:Induction of the unfolded protein response (UPR) is recognized as central to fatty liver disease (FLD) pathophysiology. This pathway may be a potential therapeutic target for FLD, as well as other diseases. However, fundamental questions as to how UPR contributes to FLD remain unanswered. Conflicting data suggest that...

journal_title：Journal of hepatology

authors： Imrie D,Sadler KC

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:Steatohepatitis (SH) is associated with mitochondrial dysfunction and excessive production of superoxide, which can then be converted into H(2)O(2) by SOD2. Since mitochondrial GSH (mGSH) plays a critical role in H(2)O(2) reduction, we explored the interplay between superoxide, H(2)O(2), and mGSH in n...

journal_title：Journal of hepatology

authors： von Montfort C,Matias N,Fernandez A,Fucho R,Conde de la Rosa L,Martinez-Chantar ML,Mato JM,Machida K,Tsukamoto H,Murphy MP,Mansouri A,Kaplowitz N,Garcia-Ruiz C,Fernandez-Checa JC

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed at comparing overall and liver-related mortality rates, observed in HIV positive subjects followed-up in the Cohorts of Spanish Network on HIV/AIDS Research stratified by HCV co-infection status, with the expected mortality of the general population of same age and sex in Spain, for the perio...

journal_title：Journal of hepatology

authors： Hernando V,Perez-Cachafeiro S,Lewden C,Gonzalez J,Segura F,Oteo JA,Rubio R,Dalmau D,Moreno S,Amo JD,CoRIS.

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) infection was hyperendemic in Taiwan before the implementation of the universal infant hepatitis B immunization program, which was launched in 1984. Five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program....

journal_title：Journal of hepatology

authors： Ni YH,Chang MH,Wu JF,Hsu HY,Chen HL,Chen DS

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:Insulin resistance, fibrosis and steatosis are established predictors of response to peg-interferon/ribavirin therapy in chronic hepatitis C (CHC). Several host genetic polymorphisms (IL28B, PNPLA3) modify treatment-outcome, the degree of steatosis or fibrosis. The aim of our study was to evaluate the...

journal_title：Journal of hepatology

authors： Stättermayer AF,Rutter K,Beinhardt S,Scherzer TM,Stadlmayr A,Hofer H,Wrba F,Steindl-Munda P,Krebs M,Datz C,Trauner M,Ferenci P

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. We analyzed pretreatment factors useful for predicting sustained virological response (SVR), especially interleukin (IL) 28B polymorphism and Homeostasis Model Assessment of In...

journal_title：Journal of hepatology

authors： Ogawa E,Furusyo N,Murata M,Ikezaki H,Ihara T,Hayashi T,Toyoda K,Taniai H,Okada K,Kainuma M,Hayashi J

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND & AIMS:Visceral adiposity is associated with hepatic steatosis, inflammation, and fibrosis in non-alcoholic fatty liver disease (NAFLD). The visceral adiposity index (VAI), a novel marker of visceral fat distribution and dysfunction, has been correlated with histology in hepatitis C. We assessed the ability ...

journal_title：Journal of hepatology

authors： Vongsuvanh R,George J,McLeod D,van der Poorten D

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:To develop an in situ molecular signature to predict postsurgical recurrence in hepatocellular carcinoma (HCC) patients. METHODS:Immunohistochemistry was performed using tissue microarrays containing both tumoral and peri-tumoral regions of the advancing tumor edge from 336 HCC patients (289 were pos...

journal_title：Journal of hepatology

authors： Xu J,Ding T,He Q,Yu XJ,Wu WC,Jia WH,Yun JP,Zhang Y,Shi M,Shao CK,Pan WD,Yin XY,Min J,Zhuang SM,Zheng L

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:Blocking intestinal bile acid (BA) absorption by inhibiting or inactivating the apical sodium-dependent BA transporter (Asbt) classically induces hepatic BA synthesis. In contrast, blocking intestinal BA absorption by inactivating the basolateral BA transporter, organic solute transporter alpha-beta (...

journal_title：Journal of hepatology

authors： Lan T,Rao A,Haywood J,Kock ND,Dawson PA

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is n...

journal_title：Journal of hepatology

authors： Peiseler M,Sebode M,Franke B,Wortmann F,Schwinge D,Quaas A,Baron U,Olek S,Wiegard C,Lohse AW,Weiler-Normann C,Schramm C,Herkel J

更新日期：2012-07-01 00:00:00

abstract：:Portal vein thrombosis is not uncommon in candidates for transplantation. Partial thrombosis is more common than complete thrombosis. Despite careful screening at evaluation, a number of patients are still found with previously unrecognized thrombosis per-operatively. The objective is to recanalize the portal vein or,...

journal_title：Journal of hepatology

authors： Francoz C,Valla D,Durand F

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND & AIMS:Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the prognostic value of imaging-ba...

journal_title：Journal of hepatology

authors： Personeni N,Bozzarelli S,Pressiani T,Rimassa L,Tronconi MC,Sclafani F,Carnaghi C,Pedicini V,Giordano L,Santoro A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND & AIMS:TMC435 is an investigational, once-daily, oral NS3/4A protease inhibitor currently in phase III development for the treatment of hepatitis C virus (HCV) infection. Phase I and II studies in patients infected with HCV genotype 1 have demonstrated that TMC435 is generally well tolerated, has a pharmacok...

journal_title：Journal of hepatology

authors： Moreno C,Berg T,Tanwandee T,Thongsawat S,Van Vlierberghe H,Zeuzem S,Lenz O,Peeters M,Sekar V,De Smedt G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:To prospectively assess the diagnostic accuracy of the incorporation of additional magnetic resonance imaging (MRI) parameters in those based on contrast enhancement pattern for the diagnosis of solitary nodules between 5 and 20mm, detected during surveillance in patients with cirrhosis. METHODS:Betw...

journal_title：Journal of hepatology

authors： Rimola J,Forner A,Tremosini S,Reig M,Vilana R,Bianchi L,Rodríguez-Lope C,Solé M,Ayuso C,Bruix J

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic background may affect liver damage in patients with non-alcoholic fatty liver disease (NAFLD). The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibros...

journal_title：Journal of hepatology

authors： Petta S,Grimaudo S,Cammà C,Cabibi D,Di Marco V,Licata G,Pipitone RM,Craxì A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:The advent of new chronic hepatitis C virus (HCV) therapies requires characterization of patients in order to predict adequate treatment. A good candidate marker is Programmed Cell Death-1 (PD-1) which is involved in progression of HCV infection. The aim of this study was to analyse the effect of seve...

journal_title：Journal of hepatology

authors： Vidal-Castiñeira JR,López-Vázquez A,Alonso-Arias R,Moro-García MA,Martinez-Camblor P,Melón S,Prieto J,López-Rodriguez R,Sanz-Cameno P,Rodrigo L,Pérez-López R,Pérez-Álvarez R,López-Larrea C

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of cirrhosis and subsequent development of organ dysfunction (OD) requiring intensive care unit (ICU) support is rising. Historically, critically ill cirrhotics are perceived as having poor prognosis and substantial cost of care. METHODS:The aim was to prospectively analyse resource uti...

journal_title：Journal of hepatology

authors： Shawcross DL,Austin MJ,Abeles RD,McPhail MJW,Yeoman AD,Taylor NJ,Portal AJ,Jamil K,Auzinger G,Sizer E,Bernal W,Wendon JA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND & AIMS:It was recently shown that semi-annual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; however, its cost-effectiveness (CE) in the general cirrhotic population still needs to be defined. METHODS:A Markov model was built to...

journal_title：Journal of hepatology

authors： Cucchetti A,Trevisani F,Cescon M,Ercolani G,Farinati F,Poggio PD,Rapaccini G,Nolfo MAD,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Pinna AD,Italian Liver Cancer (ITA.LI.CA) Group.

更新日期：2012-05-01 00:00:00

abstract：:Since the early 1990's, hepatitis B immune globulin (HBIG) has been central to the prevention of hepatitis B virus (HBV) recurrence after liver transplantation. When used in combination with oral nucleos(t)ide analogues, HBIG prevents reinfection with HBV in ⩾90% of transplant recipients. While HBIG is highly efficaci...

journal_title：Journal of hepatology

authors： Fox AN,Terrault NA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND & AIMS:Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guideli...

journal_title：Journal of hepatology

authors： Takayasu K,Arii S,Kudo M,Ichida T,Matsui O,Izumi N,Matsuyama Y,Sakamoto M,Nakashima O,Ku Y,Kokudo N,Makuuchi M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B e antigen (HBeAg) seroconversion is an important clinical and virological "landmark" during chronic hepatitis B virus (HBV) infection. Mutant viruses carrying the precore G1896A and/or the basal core promoter (BCP) A1762T/G1764A mutations are associated with HBeAg seroconversion. However, ...

journal_title：Journal of hepatology

authors： Nie H,Evans AA,London WT,Block TM,Ren XD

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND & AIMS:miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory region and characterized its transcriptional regulation by the NFκB-dependent inflammatory pathways. METHODS:Mature miRNA expre...

journal_title：Journal of hepatology

authors： Scisciani C,Vossio S,Guerrieri F,Schinzari V,De Iaco R,D'Onorio de Meo P,Cervello M,Montalto G,Pollicino T,Raimondo G,Levrero M,Pediconi N

更新日期：2012-04-01 00:00:00

abstract：:The development of portal hypertension is a common consequence of chronic liver diseases leading to the formation of esophageal and gastric varices responsible for variceal bleeding, associated with a high mortality rate, as well as other severe complications such as portosystemic encephalopathy and sepsis. Measuremen...

journal_title：Journal of hepatology

authors： Castera L,Pinzani M,Bosch J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:Clinical cases of viral infections possibly involving the transfusion of blood components are systematically investigated. METHODS:Serological and molecular markers of hepatitis B virus were used including HBsAg, anti-HBc, anti-HBs, HBV DNA, and viral load. Full genome sequencing and phylogenetic ana...

journal_title：Journal of hepatology

authors： Niederhauser C,Candotti D,Weingand T,Maier A,Tinguely C,Stolz M,Allain JP

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:This study investigates whether the aetiologic changes in liver disease and the improved management of hepatocellular carcinoma (HCC) have modified the clinical scenario of this tumour over the last 20 years in Italy. METHODS:Retrospective study based on the analysis of the ITA.LI.CA (Italian Liver C...

journal_title：Journal of hepatology

authors： Santi V,Buccione D,Di Micoli A,Fatti G,Frigerio M,Farinati F,Del Poggio P,Rapaccini G,Di Nolfo MA,Benvegnù L,Zoli M,Borzio F,Giannini EG,Caturelli E,Chiaramonte M,Bernardi M,Trevisani F

更新日期：2012-02-01 00:00:00

abstract：:Dermatological adverse events (AEs) are an existing concern during hepatitis C virus (HCV) infection and peginterferon/ribavirin treatment. HCV infection leads to dermatological and muco-cutaneous manifestations including small-vessel vasculitis as part of the mixed cryoglobulinemic syndrome. Peginterferon/ribavirin t...

journal_title：Journal of hepatology

authors： Cacoub P,Bourlière M,Lübbe J,Dupin N,Buggisch P,Dusheiko G,Hézode C,Picard O,Pujol R,Segaert S,Thio B,Roujeau JC

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND & AIMS:To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C. METHODS:In a multi-center randomized clinical trial in Japan, on patients infected with HCV of genotype 1, 126 patients were assigned to telaprev...

journal_title：Journal of hepatology

authors： Kumada H,Toyota J,Okanoue T,Chayama K,Tsubouchi H,Hayashi N

更新日期：2012-01-01 00:00:00

abstract：:This review will highlight some of the important recent trends in liver transplantation. When possible, we will compare and contrast these trends across various regions of the world, in an effort to improve global consensus and better recognition of emerging data. ...

journal_title：Journal of hepatology

authors： Burra P,Freeman R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:Innate sensing of viral infection activates a global defense response including type I interferon (IFN) and IFN-stimulated genes (ISGs) expression. We previously reported that HCV NS3/4A protease, an essential protein in viral polyprotein processing, can abrogate antiviral signaling pathways and effec...

journal_title：Journal of hepatology

authors： Jouan L,Chatel-Chaix L,Melançon P,Rodrigue-Gervais IG,Raymond VA,Selliah S,Bilodeau M,Grandvaux N,Lamarre D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:Therapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate ...

journal_title：Journal of hepatology

authors： Mauss S,Berger F,Filmann N,Hueppe D,Henke J,Hegener P,Athmann C,Schmutz G,Herrmann E

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:To follow the local tissue delivery of doxorubicin in HCC explants from patients embolized with drug-eluting beads and to compare it with histologic modifications. METHODS:Six patients with HCC underwent chemoembolization with doxorubicin-eluting beads (caliber 100-300 μm, dose 75-150 mg) followed by...

journal_title：Journal of hepatology

authors： Namur J,Citron SJ,Sellers MT,Dupuis MH,Wassef M,Manfait M,Laurent A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Non alcoholic steatohepatitis (NASH) has no approved pharmacological therapy. Insulin sensitisers such as thiazolidinediones ameliorate insulin resistance and are a potential therapeutic option. We performed a systematic review and meta-analysis of the effect of thiazolidinediones on histological and ...

journal_title：Journal of hepatology

authors： Mahady SE,Webster AC,Walker S,Sanyal A,George J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Herpes simplex virus hepatitis is a rare, but severe disease, thus far only documented by case reports and short series. The present study was based on the SRTR registry, and included all listed patients for liver transplantation from 1985 to 2009 with a diagnosis of HSV hepatitis. METHODS:We assesse...

journal_title：Journal of hepatology

authors： Moldovan B,Mentha G,Majno P,Berney T,Morard I,Giostra E,Wildhaber BE,Van Delden C,Morel P,Toso C

更新日期：2011-12-01 00:00:00